If you’re reading this, it may be because you’re curious about PrEP, someone you trust mentioned it, or you’re quietly exploring your options for staying safe and healthy. Either way, I’m glad you’re here.
At Clinique Médicale Santé +, we frequently help patients gain a better understanding of PrEP and support them in making decisions about taking this medication. As a physician who has worked in HIV prevention for many years, I want to take a few minutes to walk you through what PrEP is, how it works, and how you can safely and confidently access it here in Quebec.
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Key Takeaways
- PrEP is a highly effective method to prevent HIV when taken as prescribed, offering up to 99% protection through sexual contact and strong protection for people who inject drugs.
- In Quebec, PrEP is available as daily pills like Truvada®, Descovy®, or as a long-acting injectable like Apretude®, with options tailored to your lifestyle and preferences.
- PrEP is for anyone at risk of HIV, not just gay men. It’s also recommended for heterosexual individuals, trans people, and those who may not know their partner’s HIV status.
What is PrEP?
PrEP stands for pre-exposure prophylaxis. The word “prophylaxis” means to prevent or control the spread of an infection or disease. PrEP is a medication you take both before and after potential HIV exposure to reduce your chances of getting infected.
PrEP is one of the many methods used by people who are HIV-negative to help prevent HIV transmission. It’s important to understand that it’s a prevention tool, not a cure. Think of it like wearing a seatbelt. It doesn’t mean you’ll be in an accident, but it’s a smart way to protect yourself just in case.
To get access to PrEP, you’ll need a valid prescription from a doctor. This healthcare professional, most likely your family doctor, will monitor any potential side effects of the medication and provide you with ongoing support. During your regular visit, you will also be tested for HIV and screened for sexually transmitted and blood-borne infections (STBBIs).
In What Forms is PrEP Medication Available?
PrEP is available in Quebec in two forms: Pills and injectables.
Pills
- Truvada®, or its generic version, which combines two ingredients: tenofovir disoproxil (TDF) and emtricitabine (FTC), which are antiretroviral drugs.
- Descovy®, another pill option approved for some individuals (but not for people who engage in vaginal sex), contains two antiretroviral drugs: emtricitabine and tenofovir alafenamide
- Apretude®, a brand name for cabotegravir, is also another type of pill used as part of HIV prevention strategies
Injectable
- Apretude® is also available as an injection and is administered once every two months to provide sustained HIV prevention for those who prefer a non-daily option.
Both pills and injectable Apretude® are effective at preventing HIV, but they work differently, and one option may be more appropriate depending on your needs, health history, and lifestyle. I’ll get to that in a moment.
What’s the Difference Between PrEP and PEP?
Some of you may be familiar with PEP (post-exposure prophylaxis) and may be wondering whether PEP and PrEP medication are equivalent. Although both medicines help fight potential HIV infections, they are used in different circumstances:
- PrEP is taken before, during, and after situations presenting a high risk of HIV exposure
- PEP (post-exposure prophylaxis) is an emergency treatment taken after a potential exposure, such as if you had unprotected sex or a condom broke.
Made from three medications, PEP must be started within 72 hours of the exposure and taken over a period of 28 consecutive days. Meanwhile, PrEP is used continuously (or intermittently, in some cases) to stay protected ahead of time.
How Does PrEP Prevent HIV?
PrEP uses a combination of two antiretroviral medications that work together to block HIV from multiplying in your body, preventing the virus from establishing an infection after exposure. It builds up in your bloodstream and tissues (like your rectum or vagina) and acts like a shield. If HIV enters your body, PrEP interferes with the virus’s ability to make copies of itself. No replication means no infection.
It doesn’t kill the virus, but it stops it from setting up shop in your system. And because HIV has to take hold to cause an infection, PrEP gives your body a major head start in staying negative.
Is PrEP Effective?
When taken as prescribed, PrEP reduces the risk of contracting HIV through sexual contact by around 99%. For individuals who inject drugs, it lowers the risk of HIV transmission by at least 74%, with some studies suggesting even greater protection when adherence is consistent.
While PrEP is highly effective at preventing HIV, it does not offer protection against other sexually transmitted infections (STIs) like chlamydia, gonorrhea, or syphilis, nor does it prevent infections such as hepatitis A, B, or C.
To stay fully protected, it’s important to combine PrEP with other prevention methods. Using condoms during sexual activity reduces the risk of most STIs, and if you use injection drugs, always using new, sterile equipment helps prevent the transmission of blood-borne infections. PrEP is one tool in a broader strategy for sexual and overall health.
How is PrEP Taken?
As mentioned earlier, PrEP medication is available in both pill and injectable forms, with a prescription from a PrEP doctor. Here is how each method works:
Daily Pill
Most people use PrEP as a once-a-day pill. It’s simple, it’s consistent, and it’s approved for all genders and all types of sexual activity. It’s also the go-to method for people who inject drugs.
PrEP doesn’t provide immediate protection—it takes time to build up in your system. For anal sex, it reaches maximum effectiveness after 7 consecutive days of daily use. For vaginal sex or protection from HIV through injection drug use, you’ll need to take it consistently for at least 21 days before you’re fully protected.
On-Demand (Intermittent) Dosing
Also called the 2-1-1 method, on-demand pre-exposure prophylaxis (PrEP) is an alternative option for men (gays, bisexuals, heterosexuals) who have sex with men, trans women, and cis heterosexual men.
Generally, it involves:
- Taking 2 pills between 2 and 24 hours before sex
- Taking 1 pill 24 hours after the first dose
- Taking 1 pill 48 hours after the first dose
This method is not recommended for people who have vaginal sex or who use injection drugs.
Injectable PrEP
Apretude® is given every two months. It’s especially useful for people who find daily pills hard to maintain or who prefer less frequent medical routines. As an injectable PrEP medication, Apretude has been recently approved by the RAMQ as a covered medication.
Who Should Consider Taking PrEP?
If you think you might need PrEP, it’s probably worth having a conversation about it. Generally speaking, PrEP drugs are intended for HIV-negative people who take part in activities involving an increased risk of exposure to HIV through sexual intercourse or drug injections.
To be a bit more specific, you might benefit from PrEP if:
- You have a sexual partner who is HIV-positive
- You sometimes have sex without a condom with a partner or partners whose HIV status you do not know
- You’ve had an STI in the last 6 months
- You use injection drugs or share needles
- You are a man who has sex with men, or a trans person with HIV risk factors
- You do sex work
- You’re in a new relationship and unsure of your partner’s HIV status
If you’re unsure, your doctor will use a confidential questionnaire to help assess your level of risk. This is done without judgment. You don’t need to justify your choices to us.
Are There Any Side Effects to PrEP?
Most people do well on PrEP, but like any medication, it can cause side effects. These usually happen in the first few weeks and may include:
- Headaches
- Dizziness
- Nausea
- Vomiting
- Stomach upset
- Fatigue
- Diarrhea
Very rarely, PrEP can affect your kidney function or bone density. That’s why, as PrEP doctors, we monitor those regularly through blood tests. If you ever feel unwell or unsure about how your body is responding, we’re here to listen, support you, and make any changes needed to keep you feeling safe and cared for.
For those who can’t tolerate TDF (in Truvada®), Descovy® may be a better option. It tends to have fewer effects on kidneys and bones, but coverage is more limited.
How Much Does PrEP Cost in Quebec?
Truvada® (and some generic) and Apretude® PrEP medications are both covered by RAMQ as well as group insurance plans. You’ll have to pay your usual deductible and co-insurance fees to access this medication.
Descovy®, on the other hand, is not covered by RAMQ. However, some private prescription drug insurance plans available through your employer may cover certain out-of-pocket expenses.
In some situations, PrEP may be available for free. For example, people under certain income levels or through community-based programs.
How To Get PrEP at Clinique Médicale Santé +?
At Clinique Médicale Santé +, getting started on PrEP is straightforward:
- Initial Appointment: We review your health history, talk about your lifestyle, and answer all your questions. Rest assured, all the information you provide will remain confidential.
- Health Check Up: We run lab tests for HIV, kidney function, hepatitis B, and STBBIs. These tests are essential to make sure PrEP is safe and appropriate for you.
- Prescription and Education: We write your prescription and talk about how and when to take it. We’ll also go over possible side effects and what to expect in your first weeks.
- Follow-Ups: Every 3 months, we check your HIV status and overall health. We keep it respectful, quick, and efficient.
You don’t need a family doctor. You don’t need a referral. Just contact us directly.
Empower Yourself with PrEP
PrEP is a safe, highly effective, and accessible way to take control of your health. Whether it’s through daily pills, on-demand use, or long-acting injections, there are options to suit a wide range of lifestyles and needs.
We’ve covered how PrEP works, who it’s for, the different forms it comes in, how to get started, and what to expect throughout the process. The bottom line is: if you’re at risk for HIV, there’s a proactive way to protect yourself—and it works.
At Clinique Médicale Santé +, we’re here to make that process as simple, respectful, and comfortable as possible. Whether you’re ready to start PrEP, have more questions, or just want to talk through your options, we’re here for you.
In addition to HIV prevention, we also offer STBBI screening, periodic medical examination and minor emergency consultations.
Contact us to book your confidential appointment.
Additional Resources on PrEP:
- https://www.catie.ca/prevention-prevention-methods/hiv-pre-exposure-prophylaxis-prep
- https://maprep.org/
- https://www.canada.ca/en/public-health/services/publications/diseases-conditions/hiv-factsheet-biomedical-prevention-prep-pep.html
- https://hivinfo.nih.gov/understanding-hiv/fact-sheets/pre-exposure-prophylaxis-prep